CAS No. 1640292-55-2

Description:
Oclacitinib, also called as PF-03394197, is a novel inhibitor of JAK family members (IC50 = 10 - 99 nM) and JAK1-dependent cytokines involved in allergy, inflammation, and pruritus (IC50 = 36 - 249 nM), without affecting a panel of 38 non-JAK kinases. It could reduce pruritus and associated inflammatory skin lesions in dogs with AD.

• Molecular Weight: 453.51
• Molecular Formula: C15H23N5O2S.C4H4O4

Purity: ≥95%

Canonical SMILES:
O=C(O)C=CC(=O)O.O=S(=O)(NC)CC1CCC(N(C=2N=CN=C3NC=CC32)C)CC1

InChI:
InChI=1S/C15H23N5O2S.C4H4O4/c1-16-23(21,22)9-11-3-5-12(6-4-11)20(2)15-13-7-8-17-14(13)18-10-19-15;5-3(6)1-2-4(7)8/h7-8,10-12,16H,3-6,9H2,1-2H3,(H,17,18,19);1-2H,(H,5,6)(H,7,8)/b;2-1-/t11-,12-;

InChIKey: VQIGDTLRBSNOBV-VQIYXBGXNA-N

• Melting Point: 135-137°C
• Solubility: Soluble in DMSO (Slightly), Methanol (Slightly, Sonicated)
• Appearance: White to Off-white Solid
• Storage: Store at -20°C under inert atmosphere

Synonyms:
Cyclohexanemethanesulfonamide, N-methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-, trans-, (2Z)-2-butenedioate (1: 1); trans-N-Methyl-4-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclohexanemethanesulfonamide maleate (1: 1); N-methyl-1-((1r,4r)-4-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclohexyl)methanesulfonamide monomaleate

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