CAS No. 1802220-02-5

Molecular Formula: C18H18FN5O2
Molecular Weight: 355.3662232

Description:
TPX-0005 is an orally available and potent ATP-competitive inhibitor of ALK/ROS1/TRK (IC50= 5.3 nM for SRC, IC50= 1.01 nM, 1.26 nM and 1.08 nM for mutant ALKs including WT ALK, ALK G1202R and ALK L1196M, respectively).

• Molecular Weight: 355.37
• Molecular Formula: C18H18FN5O2

Canonical SMILES:
CC1CNC(=O)C2=CNN3C2=NC(=NC(C4=C(O1)C=CC(=C4)F)C)C=C3

InChI:
InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11,21H,8H2,1-2H3,(H,20,25)/t10-,11+/m0/s1

InChIKey: RZNJKDGJGCKKNC-WDEREUQCSA-N

• Solubility: DMSO: ≥ 83.3 mg/mL
• Storage: Store in a cool and dry place (or refer to the Certificate of Analysis).

Synonyms:
TPX-0005; TPX 0005; TPX0005

More details are to be found on supplier website

Appearance	white powder
Purity	99% min