Description:
SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP.
- Molecular Weight: 297.36
- Molecular Formula: C16H12FN3S
Purity: >98%
Canonical SMILES:
C1CSC2=NC(=C(N21)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChI:
InChI=1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
InChIKey: YOELZIQOLWZLQC-UHFFFAOYSA-N
- Boiling Point: 476.1±55.0 °C | Condition: Press: 760 Torr
- Melting Point: 189-192°C
- Solubility: 10 mM in DMSO
- Appearance: Off-white Solid
- Application: SKF-86002 could potently inhibit LPS-induced IL-1 and TNF-α production in human monocytes. It acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase.
- Storage: 2-8°C
Synonyms:
SKF-86002; SKF 86002; SKF86002. 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole; 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene
More details are to be found on supplier website
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