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Suppliers for
Hydroxypropyl cellulose, low substituted
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Properties | CAS |
9004-64-2 |
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1 Registered suppliers
Low-substituted hydroxypropyl cellulose is a non-ionic, water insoluble functional disintegrant. It can improve stability for oxygen and water sensitive APIs and has an anti-capping effect due to the fibrous nature of the particle.
L-HPC is a low-substituted hydroxypropyl ether of cellulose within a small portion of the hydroxypropyl groups in the glucose unit. Whereas hydroxypropylcellulose (MS*=3) is soluble in both water and alcohol, L-HPC (MS*=0.2-0.4) swells in water and is insoluble.
L-HPC is used as a binder and a disintegrant for solid dosage forms. It was brought onto the market in 1977, and then listed in the JP in 1986, in the NF in 1990 and in the EP in 2016. This product exhibits a wide range of compatibility with many active substances. It is a suitable binder and disintegrant for a formulation study.
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